Editor’s Note: One Small Thing is a new series to help you take a simple step toward a healthy, impactful goal. Try this one thing and you’ll be heading in…

The matchup: Two doses of psilocybin, the active ingredient in “magic mushrooms,” against a six-week course of the popular antidepressant escitalopram, often sold as Lexapro or Cipralex. Escitalopram is one…