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Fighting Alzheimer’s one discovery at a time

by admin May 9, 2025
May 9, 2025

Photo by Michael Goderre/Boston Children’s Hospital


Health

Protecting the brain requires persistence

Beth Stevens, NIH-supported investigator of Alzheimer’s and other disorders, explains how one discovery can lead to another

Sy Boles

Harvard Staff Writer

April 30, 2025


3 min read



Part of the
Profiles of Progress
series

In efforts to fight Alzheimer’s disease, neuroscientist Beth Stevens has driven a transformation in thinking about microglial cells, which serve as an immune system for the brain.

Microglia patrol the brain for signs of illness or injury, helping clear out dead or damaged cells and selectively pruning synapses, which transmit information among neurons. Sometimes the process takes a dangerous wrong turn.

The Stevens Lab, based at Boston Children’s Hospital and the Broad Institute of MIT and Harvard, has demonstrated that aberrant pruning can contribute to Alzheimer’s disease, Huntington’s disease, and other disorders.

The work has created a foundation for new biomarkers and medicines to detect and treat neurodegenerative disease. It has the potential to affect care for the estimated 7 million Americans living with Alzheimer’s, which is incurable.

“We would never have been able to move forward without the basic science and curiosity-driven science from the beginning.” 

When she was starting out, in the early 2000s, Stevens, now an associate professor of neurology at Harvard Medical School, had no idea where her curiosity would take her.

“I was just following the science,” she said. “It was this interesting new area where the brain’s immune system was helping to sculpt synapses and circuits under normal development.”

She had a hunch about synaptic pruning — and she was right. Vital support from federal agencies helped her follow through.

“The foundation of our research, from the time I was a postdoc to the first decade of my lab, was almost entirely driven by the National Institutes of Health and other federal funding,” she said.

That foundational research doesn’t always have a clear outcome, noted Stevens, who was named a MacArthur “genius” for her work on microglia in 2015. “Someone that doesn’t think about disease implications might say, ‘Oh, Stevens Lab is studying the visual system of a mouse. They’re trying to understand how a mouse’s visual system wires up.’ It can seem like that’s so far from ever translating into anything. Who cares how a mouse might see?”

But these studies allow scientists to explore questions they couldn’t in humans, she noted — which leads to new discoveries, which lead to new understandings of disease, which lead to treatments that improve human lives. 

“Our microglial research,” Stevens said, “is a great example of an immune-related pathway and cell type that we would never have been able to move forward without the basic science and curiosity-driven science from the beginning.” 

Also in this series:

  • How just a fishing expedition helped lead to GLP-1

    Story of game-changing therapy illustrates crucial role of fundamental research breakthroughs

    May 8, 2025

  • Rewriting genetic destiny

    David Liu, Breakthrough Prize recipient, retraces path to an ‘incredibly exciting’ disease fighter: ‘This is the essence of basic science.’

    April 23, 2025

  • Long trail from 1992 discovery to 2024 Nobel

    Gary Ruvkun recounts years of research, which gradually drew interest, mostly fueled by NIH grants

    April 22, 2025

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