PagesOfWellbeing.com
  • Sleep Health
  • Medical News
  • Mental Health
  • Healthy Food
Medical News

FDA-approved smoking cessation pill helps break vaping habit

by admin May 1, 2025
May 1, 2025

Health

FDA-approved smoking cessation pill helps break vaping habit

Clinical trial shows teens and young adults had three times more success quitting than their placebo counterparts

Isabella Davis

Mass General Brigham Communications

April 25, 2025


3 min read

Teens and young adults who took varenicline — an FDA-approved, twice-daily smoking cessation pill for adults — are more than three times as likely to successfully quit vaping compared to those who received only behavioral counseling, according to a new study from Harvard-affiliated Mass General Brigham. Results are published in JAMA.

“Vaping is extremely popular among kids, and we know that this early nicotine exposure can make drugs like cocaine more addictive down the line, yet ours is the first treatment study to look at this vulnerable population,” said lead author A. Eden Evins, director of the Center for Addiction Medicine at Massachusetts General Hospital and the William Cox Family Professor of Psychiatry in the Field of Addiction Medicine at Harvard Medical School. “We wanted to help teens and young adults quit, and we found that prescribing varenicline is the best way to do that.”

According to investigators, about a quarter of 18-to-25-year-olds vaped in 2023, and roughly 8 percent of high schoolers vaped in 2024. Vapes have become a popular alternative to cigarettes with the added challenge of being easy to conceal and easy to use in public places. Yet they contain many of the same familiar health threats, like nicotine addiction, carcinogen and heavy metal exposure, and pulmonary inflammation. Exploring treatment plans is crucial to provide teens and young adults with safe, effective avenues to quit. 

Because varenicline is already approved for smoking cessation in adults, it can be prescribed for anyone aged 16 to 25 wanting to quit nicotine vaping.

To identify such a treatment avenue, the Mass General Brigham team recruited 261 participants aged 16 to 25 into a randomized clinical trial. Participants were sorted into three treatment groups. The first was varenicline, weekly behavioral counseling, and access to a free text support service called “This is Quitting.” The second was placebo pills, weekly behavioral counseling, and the text service. The third was the text service alone. Each group was treated for 12 weeks, then checked on monthly for another 12 weeks post-treatment.

Each week, participants reported whether they had successfully quit vaping, and their responses were verified with cotinine saliva tests. At the end of 12 weeks of treatment and at three-month follow-up, the varenicline group had the highest quitting success rate. At 12 weeks, 51 percent of varenicline users had stopped vaping, compared to 14 percent of placebo users and 6 percent of text-only users. At 24 weeks, 28 percent of varenicline users had stopped vaping, compared to 7 percent of placebo users and 4 percent of text-only users.

These findings demonstrate the importance of medication to help young people who are addicted to nicotine quit vaping, since the varenicline group had three times more success quitting vaping than their placebo counterparts — despite both engaging in behavioral therapy. Further research is needed to explore the potential impact of other therapeutic approaches, as well as to look at even younger people who use nicotine vapes.

Because varenicline is already approved for smoking cessation in adults, it can be prescribed for anyone aged 16 to 25 wanting to quit nicotine vaping.

“Not only was varenicline effective in this age group — it was safe. Crucially, we didn’t see any participants that quit vaping turn to cigarettes,” said Randi Schuster, founding director of the Center for School Behavioral Health at MGH and associate professor of psychology in the Department of Psychiatry, HMS. “Our findings illustrate the effectiveness and safety of this therapy to address the urgent public health concern of adolescents addicted to nicotine because of vapes.”


This study was funded by the National Institutes of Health.

previous post
Stopping the bleeding
next post
U.S. pregnancy-related deaths continuing to rise

You may also like

For some, the heart attack is just the...

August 28, 2025

Dr. Robot will see you now?

August 28, 2025

Brain implants that don’t leave scars

August 27, 2025

Keeping kids safe in extreme heat

August 26, 2025

‘Hopeful message’ on brain disease

August 22, 2025

Could lithium explain — and treat — Alzheimer’s?

August 21, 2025

A setback to research that offered hope for...

August 21, 2025

Is dirty air driving up dementia rates?

August 19, 2025

Getting to the root of teen distracted driving

August 14, 2025

Going to bed earlier may help you hit...

August 12, 2025
Join The Exclusive Subscription Today And Get Premium Articles For Free

    Your information is secure and your privacy is protected. By opting in you agree to receive emails from us. Remember that you can opt-out any time, we hate spam too!

    Recent Posts

    • For some, the heart attack is just the beginning 

      August 28, 2025
    • Dr. Robot will see you now?

      August 28, 2025
    • Brain implants that don’t leave scars

      August 27, 2025
    • Keeping kids safe in extreme heat

      August 26, 2025
    • ‘Hopeful message’ on brain disease

      August 22, 2025
    • Contact us
    • Privacy Policy
    • Terms & Conditions
    • Email Whitelisting

    Copyright © 2025 PagesOfWellbeing.com All Rights Reserved.


    Back To Top
    PagesOfWellbeing.com
    • Sleep Health
    • Medical News
    • Mental Health
    • Healthy Food